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MD Biosciences成立于1991年,总部位于瑞士,在美国、加拿大和英国设有办事处。旗下MD Bioproducts部门主要产品涉及肿瘤、心血管、细胞培养、内分泌、炎症、代谢疾病、神经科学、疼痛、肾脏/肝脏功能等领域。产品包括抗体 (软骨蛋白聚糖、胶原蛋白、激素、神经药物)、细胞培养相关试剂 (胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂 (关节炎诱导抗体混合、弗氏佐剂
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MD Bioproducts/Aggrecan Antibody, N-terminal neoepitope DIPEN/1042002/100 ug

MD Bioproducts/Aggrecan Antibody, N-terminal neoepitope DIPEN/1042002/100 ug
  • MD Bioproducts/Aggrecan Antibody, N-terminal neoepitope DIPEN/1042002/100 ug
商品介绍
Overview: 

Proteoglycansarecategorieddependinguponthenatureoftheirglycosaminoglycanchains(chondroitinsulfate,dermatansulfate,heparansulphateandkeratansullfate)aswellascharacterizedbysize. 

Aggrecanisalargeaggregatingproteoglycanofarticularcartilage.Itisfoundalsoinaortatissue,discs,tendonsandintheperineuronalnet.ItisresponsIBLeforhydratingcartilage,givingitcompressibilityandresilianceduringjointloADIng,therebyplayingamajorroleinthenormalfunctionofcartilage.Depletionofglycosaminoglycanbearingaggrecanfragmentsisoneoftheearliesteventsincartilagedestruction. 

 

A)Aggrecanmonomershowingproteolyticcleavagesites

B)Aggregateshowingaggrecanmonomersboundtohyaluronicacid

 

Aggrecan

Data/Specifications: 

Immunogen:DIPENsyntheticpeptideconjugate.

 

Clone:BC-4

 

Host:Mouse

 

Myeloma:x63-Ag8.653

 

Isotype:IgG1

 

LightChaintype:kappa

 

Specificity:RecognizestheN-terminalneoepitopesequence(...DIPEN)generatedatthe“MMPcleavage site”afterMMPcatabolismintheinterglobulardomainofaggrecanbetweenaminoacids ..PEN341and342FFG.

 

Cross-reactivity:Thisantibodycross-reactswithhuman,Rat,guineapig,horse,andPig.

 

Purity:AffinitypurifiedonproteinG

 

Form:Liquid,1mL/vial

 

Concentration:0.1mg/mL

 

Storage:-20°C

How_To_Use:

Applications: 

 

  • Western-Blotting- Suggesteddilution:1:100 Detectsaabandofapproximately60kDa
  • ELISA
  • IHC

 

 

TechnicalNotes:

ThisantibodyshouldworkinIHConformalin-orparaformaldehyde-fixedparaffinembedded

sectionsaswellaseitheralcohol-fixedfrozensectionsorun-fixedsnap-frozensections.

Samplesareusuallydeglycosylatedusing0.01UnitsChondroitinaseABC(Sigma),0.01

UnitsKeratanase(Seikagaku)and0.0001UnitsKeratanaseII(Seikagaku)per10μgS-GAG

ofnon-deglycosylatedaggrecanforoptimalepitoperecognitioninSDS-PAGEandimmunohistochemistry

(1,2).

品牌介绍

MD Biosciences成立于1991年,总部位于瑞士,在美国、加拿大和英国设有办事处。旗下MD Bioproducts部门主要产品涉及肿瘤、心血管、细胞培养、内分泌、炎症、代谢疾病、神经科学、疼痛、肾脏/肝脏功能等领域。产品包括抗体 (软骨蛋白聚糖、胶原蛋白、激素、神经药物)、细胞培养相关试剂 (胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂 (关节炎诱导抗体混合、弗氏佐剂、胶原蛋白II等)、ELISA试剂盒、同型对照、天然蛋白以及重组蛋白。

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