请使用支持JavaScript的浏览器! mdbioproducts-antibodies-MD Bioproducts/Aggrecan Antibody, N-terminal neoepitope DIPEN/1042002/100 ug
主营:细胞培养相关试剂 (胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂
banner
当前位置: 首页 > 产品中心 > antibodies > MD Bioproducts/Aggrecan Antibody, N-terminal neoepitope DIPEN/1042002/100 ug
公司介绍
MD Biosciences成立于1991年,总部位于瑞士,在美国、加拿大和英国设有办事处。旗下MD Bioproducts部门主要产品涉及肿瘤、心血管、细胞培养、内分泌、炎症、代谢疾病、神经科学、疼痛、肾脏/肝脏功能等领域。产品包括抗体(软骨蛋白聚糖、胶原蛋白、激素、神经药物)、细胞培养相关试剂(胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂(关节炎诱导抗体混合、弗氏佐剂、胶原蛋白II等)、ELISA试剂盒、同型对照、天然蛋白以及重组蛋白。
问答列表

    暂无问答

MD Bioproducts/Aggrecan Antibody, N-terminal neoepitope DIPEN/1042002/100 ug

  • 产品编号: 1042002
  • 美  元  价: $0.00
  • 会  员  价: 待定
  • 品       牌: MD Bioproducts
  • 产       地: 美国
  • 公       司: MD Bioproducts
  • 产品分类: ref="." class="index">首页 > MD Bioproducts/Aggrecan Antibody, N-terminal neoepitope DIPEN/1042002/100 ug
  • 公司分类: antibodies
:100 ug
MD Bioproducts/Aggrecan Antibody, N-terminal neoepitope DIPEN/1042002/100 ug
  • MD Bioproducts/Aggrecan Antibody, N-terminal neoepitope DIPEN/1042002/100 ug
商品介绍
Overview: 

Proteoglycans are categoried depending upon the nature of their glycosaminoglycan chains (chondroitin sulfate, dermatan sulfate, heparan sulphate and keratan sullfate) as well as characterized by size. 

Aggrecan is a large aggregating proteoglycan of articular cartilage. It is found also in aorta tissue, discs, tendons and in the perineuronal net. It is responsIBLe for hydrating cartilage, giving it compressibility and resiliance during joint loADIng, thereby playing a major role in the normal function of cartilage. Depletion of glycosaminoglycan bearing aggrecan fragments is one of the earliest events in cartilage destruction. 

 

A) Aggrecan monomer showing proteolytic cleavage sites

B) Aggregate showing aggrecan monomers bound to hyaluronic acid

 

Aggrecan

Data/Specifications: 

Immunogen: DIPEN synthetic peptide conjugate.

 

Clone: BC-4

 

Host: Mouse

 

Myeloma: x63-Ag8.653

 

Isotype: IgG1

 

Light Chain type: kappa

 

Specificity: Recognizes the N-terminal neoepitope sequence (...DIPEN) generated at the “MMP cleavage site” after MMP catabolism in the interglobular domain of aggrecan between amino acids ..PEN341 and 342FFG.

 

Cross-reactivity: This antibody cross-reacts with human, Rat, guinea pig, horse, and Pig.

 

Purity: Affinity purified on protein G

 

Form: Liquid, 1 mL/vial

 

Concentration: 0.1 mg/mL

 

Storage: -20° C

How_To_Use:

Applications: 

 

  • Western-Blotting - Suggested dilution: 1:100 Detects a a band of approximately 60 kDa
  • ELISA
  • IHC

 

 

Technical Notes:

This antibody should work in IHC on formalin- or paraformaldehyde-fixed paraffin embedded

sections as well as either alcohol-fixed frozen sections or un-fixed snap-frozen sections.

Samples are usually deglycosylated using 0.01 Units Chondroitinase ABC (Sigma), 0.01

Units Keratanase (Seikagaku) and 0.0001 Units Keratanase II (Seikagaku) per 10μg S-GAG

of non-deglycosylated aggrecan for optimal epitope recognition in SDS-PAGE and immunohistochemistry

(1, 2).

品牌介绍

MD Biosciences成立于1991年,总部位于瑞士,在美国、加拿大和英国设有办事处。旗下MD Bioproducts部门主要产品涉及肿瘤、心血管、细胞培养、内分泌、炎症、代谢疾病、神经科学、疼痛、肾脏/肝脏功能等领域。产品包括抗体 (软骨蛋白聚糖、胶原蛋白、激素、神经药物)、细胞培养相关试剂 (胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂 (关节炎诱导抗体混合、弗氏佐剂、胶原蛋白II等)、ELISA试剂盒、同型对照、天然蛋白以及重组蛋白。

自营商城图标
厂家直采
全球直采模式 正品优价
正品保障图标
正品保障
厂家直发 有线跟踪
解放采购图标
正规清关
CIF100%正规报关,提供发票
及时交付图标
及时交付
限时必达 不达必赔
在线客服
客服电话

4000-520-616

微信交流