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MD Biosciences成立于1991年,总部位于瑞士,在美国、加拿大和英国设有办事处。旗下MD Bioproducts部门主要产品涉及肿瘤、心血管、细胞培养、内分泌、炎症、代谢疾病、神经科学、疼痛、肾脏/肝脏功能等领域。产品包括抗体 (软骨蛋白聚糖、胶原蛋白、激素、神经药物)、细胞培养相关试剂 (胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂 (关节炎诱导抗体混合、弗氏佐剂
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MD Bioproducts/ArthritoMab™ Antibody Cocktail for C57BL/6/CIA-MAB-2C/50 mg

MD Bioproducts/ArthritoMab™ Antibody Cocktail for C57BL/6/CIA-MAB-2C/50 mg
  • MD Bioproducts/ArthritoMab™ Antibody Cocktail for C57BL/6/CIA-MAB-2C/50 mg
商品介绍
Overview: 

Collagen-inducedarthritis(CIA)inmiceiswidelyusedasanexperimentalmodelforrheumatoidarthritis(RA)inhumans.CIAismediatedbyautoantibodies,whichbindtoaparticularregionoftypeIIcollagen(CII).TheABIlitytoinducearthritisusingthisarthritogenicantibodycocktailprovidesanefficientprotocolfortheinductionofantibody-mediatedarthritisthatcanbeusedasashorter,moresynchronizedalternativetotheCIAmodel.

 

BenefitsoftheCAIAmodel

  • Lengthofstudy:Arthritisdevelopsinmicetypicallywithin24-48hrallowingthecompletionofastudywithin2weeksreducingthenumberofassessmentsandscoringperiods.
  • Reducedgroupsize:Rateofincidenceisnearly100%dependingonthestrainallowingforsmallergroupsizes.
  • Synchronization:onsetofdiseaseissynchronizedbetweenanimalssimplifyingtreatmentschedules.
  • Steady&ControlledDiseaseProgression:evaluatevariousregimeswithasteadydiseaseprogression.Norapid&severediseasespikestocontendwith.
  • Susceptibility:Inducearthritisintransgenicstrainswithaslittleas2mgofAntibody.

 

ArthritoMab antibody cocktail for induction in C57Bl/6 strains

Comparison

 ArthritoMab™Competitor

EpitopesRecognized

CB11,CB10,CB8CB11only
DiseaseProgressionSteady&ControlledRapid&Severe
PawinvolvementConsistent&PredominantelyrearVariable&unpredictable
AmountrequiredforC57Bl/62mg(25animalspervial)
5mg(8animalspervial)


Abreviations:

  • Anti-CollagenInducedarthritis(ACIA)
  • MonoclonalAntibodyinducedarthritis(mAb-RA)
  • CollagenAntibodyInducedArthritis(CAIA)

 

Data/Specifications: 

    Epitopespecificity

    TheclassicCIAmodelismediatedbyautoantibodieswhichbindtotypeIIcollagenandcomplement.InmiceaswellashumanRApatients,theantibodyresponsethatbestcorrelateswithdiseaseisdirectedagainsttheC1,J1andU1epitopes.TheArthritoMab™arthritogeniccocktailof4monoclonalantibodiesbindstothesewell-definedepitopesC11b,J1,D3andU1,whicharespreadovertheentireCII(CB8,CB10andCB11fragments).ThispossIBLyencouragesbetterimmunecomplexformationonthecartilagesurfacefortheinitiationofarthritisandproducesconsistentandpredictablediseaseinall4paws(withpredominancefortherear).CompetitorproductsonlyrecognizeCB11,whichproducesvariablediseasethatcancontributetounpredictableinvolvementinthepaws(sometimesmorefrontpawinvolvmentandothertimesmorerearinvolvement).

    epitope specificity of Arthritomab antibody cocktial for inducing arthritis 

     

    Susceptibility 

    • Balb/c
    • DBA/1
    • B10.RIII
    • C57Bl/6
    Histopathology:
    SimilarfeaturestotheCIAmodelwithonly2mgantibodyinC57Bl/6JN
    histology in C57 using 2 mg Arthritomab antibody cocktail for arthritis induction

    How_To_Use:

    Applications

     

    • Invivo:inducediseaseinthecollagenantibodyinducedarthritismodel
    • bindcollageninvivo
    • impaircartilageformationbychondrocytesinvitro
    • inhibitassemblyofCIIinvitro
    • inhibitcollagenfibrillogenesisinvitro
    FortheInductionofArthritisintheCollagenAntibodyInducedArthritisModel:
    1. AdmiNISTerantibodycocktailonday0*
    2. BoostwithLPSonday3
    3. Terminateonday12
    *Amountofcocktailwillvarydependingonanimalsourceandstrain,housingconditions,feedandwater.Eachlabmustoptimizefortheirownconditions. 

    DownloadawhitepaperonusingtheCAIAmodelasanalternativetoCIAorK/BxNserumtransfermodels. 

    品牌介绍

    MD Biosciences成立于1991年,总部位于瑞士,在美国、加拿大和英国设有办事处。旗下MD Bioproducts部门主要产品涉及肿瘤、心血管、细胞培养、内分泌、炎症、代谢疾病、神经科学、疼痛、肾脏/肝脏功能等领域。产品包括抗体 (软骨蛋白聚糖、胶原蛋白、激素、神经药物)、细胞培养相关试剂 (胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂 (关节炎诱导抗体混合、弗氏佐剂、胶原蛋白II等)、ELISA试剂盒、同型对照、天然蛋白以及重组蛋白。

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