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MD Biosciences成立于1991年,总部位于瑞士,在美国、加拿大和英国设有办事处。旗下MD Bioproducts部门主要产品涉及肿瘤、心血管、细胞培养、内分泌、炎症、代谢疾病、神经科学、疼痛、肾脏/肝脏功能等领域。产品包括抗体 (软骨蛋白聚糖、胶原蛋白、激素、神经药物)、细胞培养相关试剂 (胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂 (关节炎诱导抗体混合、弗氏佐剂
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MD Bioproducts/Goat anti-mouse IgD, Antiserum/2057001/1 ml

MD Bioproducts/Goat anti-mouse IgD, Antiserum/2057001/1 ml
  • MD Bioproducts/Goat anti-mouse IgD, Antiserum/2057001/1 ml
商品介绍
Overview: 

ImmunoglobulinD(IgD)isanantibodyisotypethatisfoundprimarilyonmatureB-cellsaspartoftheB-cellreceptor(BCR)complex.ClusteringoftheBCRduetoantigenbindingleadstoactivationofB-cellsthatcanresultinanumberofoutcomesincludingproliferation,differentiation,andtolerance.

TheABIlitytoactivateB-lymphocytesusingpolyclonalantiserarecognizinganti-IgDisusefulforthestudyofB-cellfunction(Finkelman,etal.,1985;Nguyen,etal.,2014).Anti-IgDisparticularlysuitedforthisapplicationbecausesolubleIgDispresentinextremelylowlevelsinserum(<0.25%oftotalimmunoglobulin)andwillnotinterferewithB-cellactivationinawholeblood-basedorinvivosetting.(Incontrast,highlevelsofcirculatingIgMwilltypicallyblockB-cellactivationbyanti-IgMinwholeblood.)SuchamethodologycanbeusedtorapidlytesttheefficacyofB-cellinhibitoryagentsinacellular,exvivo,orinvivocontext(Coffey,etal.,2012).

Data/Specifications: 

 

Format: 1mlpervial

 

Host: Goat

 

Reactivity: MouseimmunoglobulinCδchain

 

Buffer: None

 

Preservative: Preservative-freeforinvivoapplication,0.2μmsterile-filtered

 

Storage: Shorttermat2-8°C.Forlongtermstorage,-80°Cisrecommended.Avoidmultiplefreeze-thawcycles.Shouldbekeptsterile.Canbere-filteredifnecessary.

 

Expiration: Seeviallabel

How_To_Use:

IgDcross-linkingonBcellsisanidealmethodfortheassessmentofacutepolyclonalBcellactivationacrossmultiplestrainsofmice.Followinganti-IgDinjection(100μl/mouse,i.v.),peripheralBcellsarerapidlyactivatedasevidencedbyup-regulationofCD86andCD69.ActivatedBcellswillsecreteeffectorcytokines(IL-4)andacquireeffectorfunction(secretionofIgEantibodies)within5-7days.Anti-mouseIgDantibodycanalsobeusedtoinducefunctionalBcellsinvitro.ThismodelsystemisidealforspecificexaminationofkeypathwaysandplayersinthefunctionalactivationofperipheralBcellsinvivo. 

品牌介绍

MD Biosciences成立于1991年,总部位于瑞士,在美国、加拿大和英国设有办事处。旗下MD Bioproducts部门主要产品涉及肿瘤、心血管、细胞培养、内分泌、炎症、代谢疾病、神经科学、疼痛、肾脏/肝脏功能等领域。产品包括抗体 (软骨蛋白聚糖、胶原蛋白、激素、神经药物)、细胞培养相关试剂 (胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂 (关节炎诱导抗体混合、弗氏佐剂、胶原蛋白II等)、ELISA试剂盒、同型对照、天然蛋白以及重组蛋白。

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