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MD Biosciences成立于1991年,总部位于瑞士,在美国、加拿大和英国设有办事处。旗下MD Bioproducts部门主要产品涉及肿瘤、心血管、细胞培养、内分泌、炎症、代谢疾病、神经科学、疼痛、肾脏/肝脏功能等领域。产品包括抗体(软骨蛋白聚糖、胶原蛋白、激素、神经药物)、细胞培养相关试剂(胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂(关节炎诱导抗体混合、弗氏佐剂、胶原蛋白II等)、ELISA试剂盒、同型对照、天然蛋白以及重组蛋白。
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MD Bioproducts/HtrA4 Human Recombinant Protein, truncated, His-tagged/5044013/5 µg

  • 产品编号: 5044013
  • 美  元  价: $0.00
  • 会  员  价: 待定
  • 品       牌: MD Bioproducts
  • 产       地: 美国
  • 公       司: MD Bioproducts
  • 产品分类: ref="." class="index">首页 > MD Bioproducts/HtrA4 Human Recombinant Protein, truncated, His-tagged/5044013/5 µg
  • 公司分类: natural and recombinant proteins
:5 µg
MD Bioproducts/HtrA4 Human Recombinant Protein, truncated, His-tagged/5044013/5 µg
  • MD Bioproducts/HtrA4 Human Recombinant Protein, truncated, His-tagged/5044013/5 µg
商品介绍
Overview: 

HtrA4 is a secreted human serine protease is supposed to form oligomers of identical protein chains as revealed by X-ray analysis for the bacterial HtrA protein DegP [1]. Polypeptide chains of human HtrA4 consist of several domains: An N-terminal insulin-like growth factor domain is followed by a Kazal-type serine protease inhibitor domain, a linker region, a trypsin-like protease domain and a PDZ domain [2]. The truncated version HtrA4D covers part of the Kazal domain, the serine protease and the PDZ domain. The function of HtrA4 is a probable serine protease. No information is available yet on physiological substrates or interacting proteins.

Data/Specifications: 

Purity: Recombinant HtrA4 appears as a major protein of about 38 kDa in SDS-PAGE (> 90% of total protein). Due to minor N-terminal truncation of the protein it may appear as a double band.

 

Enzymatic Activity: Proteolytic activity of recombinant human HtrA4 is documented by digestion of ß-casein.  0.5 mg ß-casein/ml are completely digested by 10 μg/ml HtrA4 within 24 hours at 37 °C (see PDF insert).

 

StABIlity & Storage: Recombinant human HtrA4 is stable until the expiry date given on the label when stored at -70 °C. Repeated freezing and thawing should be avoided. Note: Upon freezing, a faint precipitate may form which contains HtrA4. This precipitate was shown to contain catalytically active HtrA4 in a casein digest. Therefore, we recommend vortexing the protein solution before use.

 

Applications: Recombinant HtrA4 allow detailed studies of the structure and function of this protease. The enzyme is used to screen for inhibitors and to characterize inhibitor actions. Recombinant HtrA4 can also serve as standard in enzymatic and immunochemical assays.

品牌介绍

MD Biosciences成立于1991年,总部位于瑞士,在美国、加拿大和英国设有办事处。旗下MD Bioproducts部门主要产品涉及肿瘤、心血管、细胞培养、内分泌、炎症、代谢疾病、神经科学、疼痛、肾脏/肝脏功能等领域。产品包括抗体 (软骨蛋白聚糖、胶原蛋白、激素、神经药物)、细胞培养相关试剂 (胶原蛋白、细胞增殖检测、支原体PCR检测)、疾病诱导试剂 (关节炎诱导抗体混合、弗氏佐剂、胶原蛋白II等)、ELISA试剂盒、同型对照、天然蛋白以及重组蛋白。

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